Catalytic Arylation Methods – From the Academic Lab to Industrial Processes, C.S. Marques and A.J. Burke, Wiley-VCH,  2014 .

Active Pharmaceutical Ingredients in Synthesis, Catalytic Processes in Research and Development, A.J. Burke, C.S. Marques, G.J. Hermann and Nicholas Turner, Wiley-VCH, 2018 , ISBN 978-3-527-34241-9. Available in book shops and on-line.

6.12 Asymmetric Epoxidations and Sulfoxidations ,  AJ Burke , E.P. Carreiro, Comprehensive Inorganic Chemistry II , Asymmetric Catalysis, vol. 6, pp-309-82,  J. Reedijk, K. Poeppelmeier (editors). ISBN: 9780080977744.

Amino-Cinchona derivatives in Organocatalysis, AJ. Burke  and G.J. Hermann, (M. Benaglia, ed.), ORGANOCATALYSIS: STEREOSELECTIVE REACTIONS AND APPLICATIONS IN ORGANIC SYNTHESIS, Walter de Gruyter GmbH, in press.

PAPERS (Selected  examples)

1. N -1,2,3-Triazole-Isatin Derivatives for Cholinesterase and b-Amyloid Aggregation Inhibition: A Comprehensive Bioassay Study,   Carolina S. Marques, Óscar López, Donatella Bagetta, Elisabete P. Carreiro, Sabrina Petralla, Manuela Bartolini, Matthias Hoffmann, , Stefano Alcaro, Barbara Monti, Maria Laura Bolonesa, Michael Decker, José G. Fernández-Bolaños and Anthony J. Burke , Bioorganic Chem. 2020 , 98, 103753 (1-13).

2. A photo-switchable “host-guest” approach for food safety applications: a photo-responsive molecularly imprinted-based sorbent for the selective enrichment of dimethoate from olive oil samples, Raquel Garcia, Elisabete P. Carreiro, João P. Prates Ramalho, Anthony J. Burke , João Carlos Lima, Marco D.R. Gomes da Silva, Ana Maria Costa Freitas, Maria João Cabrita, Analytica Chimica Acta . 2018 ,  1035, 60-69.

3. Pd-Catalyzed one-pot Borylation/Intramolecular Asymmetric Arylation on α-ketimino amides: Innovative Approach to Chiral 3-Amino-2-oxindols, C.S. Marques, S.E. Lawrence, A.J. Burke , Synlett , 2018, 29, 497 502, .

4. A magnetic controllable tool for the selective enrichment of dimethoate from olive oil samples: a responsive molecular imprinting-based approach, E.P. Carreiro, J. P. Prates, Ramalho, José Mirão, Anthony J. Burke,  Marco D.R. Gomes da Silva, Ana Maria Costa Freitas, Maria J. Cabrita, Food Chemistry , Volume 254 , 15 July 2018 , Pages 309-316. .

5. Stereoselective metal-free reduction of chiral imines in batch and in flow mode: a convenient strategy for the synthesis of chiral Active Pharmaceutical Ingredients, Davide Brenna, Maurizio Benaglia, 3.  Enantioselective Rh(I)-Catalyzed additions of arylboronic acids to N -1,2,3-Triazole-Isatin Derivatives: Accessing N -(1,2,3-Triazolmethyl)-3-Hydroxy-3-aryloxindoles, Carolina S. Marques, Anthony J. Burke , ChemCatChem, 2016 , 8, 3518-26.

6. Sequential Alcohol Oxidation/putative Homo Claisen-Tishchenko-Type Reaction to give esters: A Key process in accessing Novel Biologically Active Lactone Macrocycles, Hugo Viana, Albertino Goth, Patrícia Bacalhau, A. Teresa Caldeira, M. Rosário Martins, Anthony J. Burke  RSC Advances , 2016 , 6, 63214 – 63223.

7. Modular Catalytic Synthesis of 3-Amino-3-Aryl-2-Oxindoles: Rh-Catalysis with Novel Isatin-Derived N -Boc Ketimines, C.S. Marques and A.J. Burke , Eur. J. Org. Chem.  2016 , 806-812, ejoc.201501399.

8. New Click-Chemistry Methods for 1,2,3-triazoles: Synthesis: Recent Advances and Applications, J. Totobenazara, A.J. Burke ,  Tetrahedron Letters Digests, 2015 , 56, 2853-59. Available on-line 9 Abril 2015. . It is currently the 4th most cited Tetrahedron Letter paper since 2015.

9. Tailor-Made Molecularly Imprinted Polymers for Dimethoate and Deltamethrin Recognition: Synthesis, Characterization and Chromatographic Evaluation, Marco Simões, Nuno Martins, Maria João Cabrita, A.J. Burke , Raquel Garcia, Journal of Polymer Research 2014 , 21:368 (DOI: 10.1007/s10965-014-0368-9).

10. Asymmetric Catalytic Arylation of Ethyl Glyoxylate using Organoboron Reagents and Rh(I)-Phosphane and Phosphane-Phosphite Catalysts, M. Dindaroğlu, H.-G. Schmalz, C.S. Marques, A.J. Burke , RSC Advances,  2014, 4, 6035-41. (DOI: 10.1039/C3ra47000h).

11.  3-Hydroxypyrrolidine and (3,4)-Dihydroxypyrrolidine Derivatives: Inhibition of rat intestinal a-Glucosidase, E. P. Carreiro, P. Louro, G. Adriano, R.N. Vannuchi, R. Guedes, A.R. Costa, C. M.M. Antunes, R. C. Guedes, A.J. Burke ,  Bioorg. Chem.  2014 , 54 , 81-8.

12. Synthesis of novel organocatalysts derived from  Cinchona  Alkaloids for asymmetric aldol reactions, Pedro Barrulas, Maurizio Benaglia, A.J. Burke ,  Tetrahedron: Asymmetry2014 ,  25 , 923-35. (4th most downloaded Tetrahedron Asymmetry paper in the last 90 days (16-10-2014).

13. Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to Aromatic α-Amino Acids: Stable Substrates for Catalytic Arylation Reactions, C.S. Marques, A.J. Burke ,  Tetrahedron, 2013 , 69, 10091-7.

14. TARTROL-derived Chiral Phosphine-Phosphite Ligands and their Performance in Enantioselective Cu-catalyzed 1,4-Addition Reactions, M. Dindaroğlu, S.Akyol, H. Şimşir, J.-M. Neudörfl, A. Burke , H.-G. Schmalz, Tetrahedron: Asymmetry, 2013 , 24 , 657-62.

15. Novel Pyrrolidinediol alpha-glucosidase inhibitors: Synthesis, Screening and Molecular Modelling, R.L. Guerreiro, E. Carreiro, L. Fernandes, T. Cardote, R. Moreira, A.T. Caldeira, R. Guedes, A.J. Burke , Bioorganic & Med Chem. 2013,  21, 1911-7.

16. Advances in the Catalytic Asymmetric Arylation of Imines using Organoboron Reagents: An Approach to Chiral Arylamines, Carolina S. Marques, Anthony J. Burke , ChemCatChem , 2011 , 4, 635-45.

17. Catalytic Enantioselective Addition of Phenylboronic Acid to Electrodeficient N -Tosylimines: Pd (II) and Rh(I) Catalysis, C. S. Marques, A. J. Burke ,   Eur. J. Org. Chem, 2010 , 1639-43.


1. Novel Picolinamide-Cinchona Organocatalysts and derivates, P. Barrulas and AJ Burke,  WO2015052656 , US9844773 , Publication date 16-April 2015.

CONFERENCE TALKS (last 7 years)

1. Asymmetric Ketimine Hydrosilylation using Chinchona-Picolinamide Organocatalysts,

7th EuChem Conference on Nitrogen Ligands, 4-7 September 2018 , University of Lisbon, faculty of sciences.

2. Brincadeiras com Catálise: Construção de Novos Medicamentos, VI Encontro Nacional de Estudantes de Química (ENEQUI), 24 March 2018 , Covilha.

3. STD-NMR-in silico  Screening: An Effective Combination for Validating ChE and MAO-B Dual Inhibition,

2nd COST MuTaLig Working Group meeting 2, 15-16 March 2018 , Tenerife Spain.

4. Fun with Cyclizations: Acessing Heterocyclic Bioactive Compounds via New Methodologies,  (Keynote speaker), 12th National Organic Chemistry Meeting/5th National Therapeutic Chemistry Meeting Portuguese Chemical Society, 17-19 January 2018 , Coimbra, Portugal.

5. Developing New Small-Molecule Cholinesterase Inhibitors: Harnessing the Power of 3-Substituted-3-Hydroxyoxindoles, World Preclinical congress, Mastering medicinal chemistry, 14-15 Nov. 2016 , Lisbon.

6. Enabling Medicinal Chemistry with Catalysis – New Cholinesterase Inhibitors for Treating Alzheimer’s Disease , 7th Spanish Portuguese Japanese Organic Chemistry Symposium (7th SPJ-OCS), June 23-26, 2015 , Seville, Spain.

7. Ten years of Catalytic (Asymmetric) Activity at CQE-UE, 10th National Meeting on Organic Chemistry-First Luso-Brasilian Symposium on Organic Chemistry, 4-6 September 2013 , Lisbon.

8. Asymmetric Ketimine Hydrosilylation using Chinchona-Picolinamide Organocatalysts,  7th EuChem Conference on Nitrogen Ligands , 4-7 September 2018 , University of Lisbon, Faculty of Sciences.

9. Synthesizing Chiral Amines the Hydrosilylation Way: Organocatalysis with Cinchona-Amides, 8th Spanish Portuguese Japanese Organic Chemistry Symposium  (8th SPJ-OCS, 9-10 Nov. 2018), Kyoto, Japan, 10 Nov. 2018 .

10. Targeting Alzheimer’s Disease with 4-Aminochromane Derivatives: Single and Dual Inhibitors, 4th COST MuTaLig Action meeting , 5th March, Ege University, İzmir Turkey, 5 and 6 March 2020 .


Coming shortly…….